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. 2020 Feb 19;11(2):134. doi: 10.1038/s41419-020-2328-0

Fig. 4. Nec-1s reduced the expression levels of DAMPs and proinflammatory cytokines except IFN in mice with IMQ-induced psoriasiform dermatitis.

Fig. 4

a Protein level of HMGB1 was quantified by western blotting in the three groups of mice. b–m Real-time quantitative PCR was performed to quantify the mRNA level of IL-1β (b), TNF-α(c), IL-6 (d), IL-17A (e), IL-17C (F), IL-17F (g), IL-22 (h), IL-23a (i), CXCL1 (j), and CCL20 (k) in the skin biopsies from mice. Symbols defined in legend apply to b–k panels in the figure. Results are representative of three independent experiments. Error bars represent mean ± standard deviation (SD). **p < 0.01 and ***p < 0.001 when compared.