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. 2020 Feb 19;10:2932. doi: 10.1038/s41598-020-60050-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Chrysin improves imiquimod (IMQ)-induced skin inflammation. Chrysin was topically applied for 1 h on the skin and ears of mice before IMQ stimulation or vehicle cream administration for six consecutive days. (A) Phenotypic change in the appearance of skin of mice for six consecutive days. (B) Macroscopic changes in mouse ears. (C) Histological sections of mouse skin stained with haematoxylin and eosin. (D) Quantification of mouse skin histology examined using the PASI score. In each group, mice were stimulated with or without IMQ after pretreatment with chrysin. We performed in vivo experiments in at least six mice per treatment group, and data represent the mean ± SEM from at least six independent experiments. *p < 0.05 was considered to be statistically significant.