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. 2020 Feb 19;10:2908. doi: 10.1038/s41598-020-59834-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A head-to-head comparison of different contact-assisted threading methods and baseline RaptorX-assisted threading method on PSICOV150 dataset. (A) mfDCA-assisted threading method (referred to as rr_mfDCA) versus baseline RaptorX-assisted threading method (referred to as rr_RAPTORX-assisted threading), (B) PSICOV-assisted threading method (referred to as rr_PSICOV) versus baseline RaptorX-assisted threading method, (C) MetaPSICOV-assisted threading method (referred to as rr_MetaPSICOV) versus baseline RaptorX-assisted threading method. Each point in each scatter plot represents joint TM-score of top ranked model predicted by baseline RaptorX-assisted threading and one of the other three contact-assisted threading methods respectively. (D) TM-score distribution of top ranked models predicted by RaptorX-assisted threading method versus mfDCA-assisted threading method (referred to as rr_mfDCA-assisted threading), (F) TM-score distribution of top ranked models predicted by RaptorX-assisted threading method versus PSICOV-assisted threading method (referred to as rr_PSICOV-assisted threading), (G) TM-score distribution of top ranked models predicted by RaptorX-assisted threading method versus MetaPSICOV-assisted threading method (referred to as rr_MetaPSICOV-assisted threading). Templates with sequence similarity >30% to the query sequence are excluded.