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. 2020 Feb 19;10:2921. doi: 10.1038/s41598-020-59890-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathological and apoptotic cell responses in colonic epithelia of ascorbate treated mice following C. jejuni infection. Starting four days before peroral C. jejuni infection on days 0 and 1, secondary abiotic IL-10^−/− mice were treated with synthetic ascorbate (ASCOR; open circles) or placebo (PLC; filled circles) via the drinking water. (A) Histopathological changes were quantitated in hematoxylin and eosin stained colonic paraffin sections applying a standardized scoring system as described in methods. (B) The average numbers of apoptotic (positive for caspase3, Casp3⁺) colonic epithelial cells from six high power fields (HPF, 400x magnification) per mouse were assessed microscopically in immunohistochemically stained large intestinal paraffin sections at day 6 post-infection. Naive mice (open diamonds) served as uninfected and untreated controls. Medians, significance levels (p-values) assessed by the one-way ANOVA test followed by Tukey correction and numbers of analyzed animals (in parentheses) are indicated. Data were pooled from four independent experiments.