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. 2020 Feb 19;10:2921. doi: 10.1038/s41598-020-59890-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Intestinal inflammatory mediator responses in ascorbate treated mice following C. jejuni infection. Starting four days before peroral C. jejuni infection on days 0 and 1, secondary abiotic IL-10^−/− mice were treated with synthetic ascorbate (ASCOR; open circles) or placebo (PLC; filled circles) via the drinking water. At day 6 post-infection. pro-inflammatory mediators including (A) nitric oxide, (B) TNF, (C) IL-6 and (D) IFN-γ were measured in supernatants of ex vivo biopsies derived from the colon as well as (E) IFN-γ concentrations assessed in mesenteric lymph nodes (MLN). Naive mice served as negative controls (open diamonds). Medians, significance levels (p-values) assessed by the Kruskall Wallis test followed by Dunns correction and numbers of analyzed animals (in parentheses) are indicated. Data were pooled from four independent experiments.