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. 2020 Feb 19;10:2939. doi: 10.1038/s41598-020-59853-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pathway analysis in VEGFR2-Fc–expressing tumors compared with Mock tumors based on RNA-Seq analysis. (a) Venn diagram showing genes that are more than 1.5 times upregulated in VEGFR2-Fc–expressing tumors compared with Mock tumors. Gene set A is defined as upregulated in Renca^VEGFR2-Fc compared with Renca^Mock. Gene set B is defined as upregulated in B16F10^VEGFR2-Fc compared with B16F10^Mock. A ∩ B shows area of intersection of gene set A and gene set B. (b) Reactome analysis of signaling pathways in A ∩ B. The top 6 pathways are shown. (c,d) RT–qPCR analysis of the mRNA levels of various FGF and FGFR family members in Mock and VEGFR2-Fc–expressing tumors. (c) Renca model; (d) B16F10 model. Data are means ± SEM. *p < 0.05 (unpaired t-test). (e,f) Levels of phospho-FGFR2, FGFR2, FGF2 in lysates extracted from Mock and VEGFR2-Fc tumors analyzed by Western Blot analysis. (e) Renca model; (f) B16F10 model.