Table 1.
Characteristics of study group.
| Parameter | Untreated Toxic adenoma n = 258 | Untreated Graves’ disease n = 62 | LT4-treated carcinoma n = 141 | P value |
|---|---|---|---|---|
| Gender female/male | 71% / 29% | 73% / 27% | 67% / 33% | 0.85 |
| Age years | 65.0 [55, 74] | 53.0 [45, 62] | 54.0 [47, 62] | <0.001 |
| BMI kg/m2 | 26.3 [23.9, 29.5] | 26.2 [23.4, 27.9] | 28.4 [24.8, 32.2] | 0.001 |
| Thyroid volume ml | 26.0 [17.0, 43] | 20.0 [14.5, 29.8] | 0 [0, 0] | <0.001 |
| Weight-adjusted LT4 dose µg/kg | – | – | 1.69 [1.52, 2.02] | – |
| TSH within range/suppressed | 23% | 31% | 36% | 0.02 |
| 77% | 69% | 64% | ||
| FT4 within range/hyperthyroid | 96% | 86% | 74% | <0.001 |
| 4% | 14% | 26% | ||
| FT3 within range/hyperthyroid | 92% | 79% | 95% | <0.001 |
| 8% | 21% | 5% | ||
| FT3 pmol/l | 5.30 [4.96, 5.81] | 5.29 [5.06, 6.08] | 5.10 [4.70, 5.70] | 0.002 |
| FT4 pmol/l | 15.3 [13.6, 17.0] | 15.7 [14.3, 18.3] | 20.6 [18.8, 23.2] | <0.001 |
| TSH mIU/l | 0.25 [0.10, 0.38] | 0.29 [0.01, 0.44] | 0.15 [0.02, 0.75] | 0.81 |
| Deiodinase activity nmol/s | 32.6 [29.3, 36.6] | 32.7 [29.2, 38.3] | 23.2 [20.9, 25.5] | <0.001 |
| TPO Ab IU/ml | – | 68.1 [36.8, 558] | – | – |
| TSR-R Ab IU/l | – | 1 [0.20, 3.5] | – | – |
Data are median [IQR] or percentages. Significance was tested with Kruskal-Wallis or chi-square test, respectively. Range refers to the reference range.