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. 2020 Feb 13;9:1423. doi: 10.3389/fonc.2019.01423

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Copyright © 2020 Yan, Sun, Wu, Wu, Hu, Sun, Liu, Ma, Liu, Xiao, Liu and Ning.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PELP1 knockdown downregulated c-Src-PI3K-Erk pathway. (A) BIOCARTA analysis of PELP1 modulation of estrogen receptor activity in human pathway. AGS and SNU-1 cells were transfected with PELP1 siRNA or a non-targeting siRNA (control) for 48 h. (B) PELP1 silencing was accompanied by downregulation of c-Src and decreased phospho-Src-Y529 protein as determined by western blot. (C) PELP1 silencing was accompanied by the downregulation of c-Src mRNA, PI3K mRNA and Erk mRNA as determined by quantitative RT-PCR. Values are the mean ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001).