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. 2020 Feb 13;9:1423. doi: 10.3389/fonc.2019.01423

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Copyright © 2020 Yan, Sun, Wu, Wu, Hu, Sun, Liu, Ma, Liu, Xiao, Liu and Ning.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PELP1 can be targeted by chlorpromazine in GC. (A) Chlorpromazine interacts with PELP1 in molecular docking model. (B) The absorbance (OD) at 450 nm wave-length was reduced in chlorproazine groups in MTT assays dose-dependently. (C1,C2) The colony formation ability of AGS and SNU-1 were inhibited with the increasing of CPZ. Transwell small chamber assay revealed CPZ suppressed the migration and invasion ability of AGS (D1,D2) and SNU-1 cell (D3,D4). (E) CPZ inhibited the protein expression of PELP1 in AGS and SNU-1. (F) PELP1 activation compromised the CPZ's inhibitory effect on GC AGS cell. Experiments were repeated 3 or 4 times. Values are the mean ± SEM (***p < 0.001).