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. 2020 Feb 19;10:2930. doi: 10.1038/s41598-020-60054-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Between-group comparison at the node-level using the AAL atlas when periventricular white matter hyperintensities (WMHs) were considered. (A) Degree centrality values of all regions in each group. The inferior orbitofrontal cortex (region #16) and the dorsal medial prefrontal cortex (region #24) are represented with black boxes. (B) The three identified regions, with corresponding degree centrality values in all groups. Significant differences are shown with asterisks. Brain images were visualized using the BrainNet Viewer⁴⁹. lw, low WMH burden; hw, high WMH burden; o, obese; no, non-obese.