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. 2020 Feb 19;10:2930. doi: 10.1038/s41598-020-60054-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Between-group comparison at the node-level using the Brainnetome atlas. (A) Degree centrality values of all regions for each group when total (left) and periventricular WMHs (right) were considered. The black boxes represent the orbitofrontal cortex (A12/47o and A11). (B) The identified brain regions when total (left) and periventricular WMHs (middle and right) were considered. (C) Degree centrality values of the identified regions in all groups. Significant differences are shown with asterisks. Brain images were visualized using the BrainNet Viewer⁴⁹. lw, low WMH burden; hw, high WMH burden; o, obese; no, non-obese.