Table 1.
Relative percentages of the three major short-chain fatty acids (SCFA) derived from microbial fermentation, following supplementation with either celecoxib (CX) or the carrier (PEG) at the (A) beginning of the incubation (0 h, n = 6).
| SCFA (%) | Ratio found in colon and stool83 | Donor 3 | Donor 4 | Donor 5 | Donor 6 | Donor 7 | Donor 8 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CX | PEG | CX | PEG | CX | PEG | CX | PEG | CX | PEG | CX | PEG | ||||||
| (A) | |||||||||||||||||
| Acetate | 60 | 60.02 | 65.71 | 35.45 | 39.30 | 63.90 | 65.32 | 59.25 | 63.42 | 40.88 | 41.84 | 49.98 | 53.97 | ||||
| Propionate | 20 | 23.20 | 21.64 | 14.84 | 14.46 | 12.63 | 12.48 | 12.83 | 11.70 | 14.20 | 13.97 | 10.61 | 10.81 | ||||
| Butyrate | 20 | 15.49 | 12.65 | 10.17 | 9.48 | 15.85 | 15.52 | 8.20 | 5.84 | 6.92 | 7.20 | 6.23 | 6.15 | ||||
| SCFA (%) | Ratio found in colon and stool83 | Donor 1 | Donor 2 | Donor 3 | Donor 4 | Donor 5 | Donor 6 | Donor 7 | Donor 8 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CX | PEG | CX | PEG | CX | PEG | CX | PEG | CX | PEG | CX | PEG | CX | PEG | CX | PEG | ||
| (B) | |||||||||||||||||
| Acetate | 60 | 49.41 | 47.15 | 74.64 | 62.51** | 22.46 | 28.97 | 33.32 | 34.76 | 73.82 | 57.87*** | 84.89 | 63.64*** | 68.12 | 67.87 | 73.99 | 69.94 |
| Propionate | 20 | 17.30 | 18.05 | 22.40 | 18.27 | 21.01 | 18.89 | 6.90 | 9.06 | 14.96 | 16.13 | 12.58 | 18.93** | 16.14 | 13.88 | 14.18 | 13.48 |
| Butyrate | 20 | 15.13 | 17.15 | 2.27 | 17.89*** | 4.83 | 11.76*** | 7.51 | 7.89 | 6.04 | 19.48*** | 2.46 | 13.01*** | 8.15 | 10.29** | 7.66 | 8.07 |
Means between treatments were not significantly different and samples from donors 1 and 2 were missed at this time point. Quantification of relative SCFA percentage was completed again when incubation was finalized after 16 h (B). N = 8; **P < 0.05; ***P < 0.0001.