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. 2020 Feb 19;10:2986. doi: 10.1038/s41598-020-59818-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Evaluation of the binding activity of the truncated mutants of HER2 ECD d^I, HER2 ECD d^I-1/2II, HER2 ECD d^I-1/2III and HER2 ECD d^I-III with GB235 as determined by ELISA. (B) Binding ability of chimeric HER2^I-III-HER3^IV and HER3^I-III-HER2^IV with GB235 as evaluated by ELISA. (C) The cross-reactivity of GB235 toward mouse, rat or human HER2 was evaluated by ELISA. (D) Binding activity of human HER2 ECD point mutants (D362N, Q374H and H456N) to GB235 as determined by ELISA. The data are expressed as the mean ± SEM of three independent experiments.