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. 2020 Feb 19;10:2947. doi: 10.1038/s41598-020-59716-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Narciclasine reduced the systemic levels of inflammatory cytokines in neonatal septic rats. The neonatal rats were subjected to E. coli induced sepsis (n = 6 per group) in the presence or absence of narciclasine (NC, 0.1, 1 and 3 mg/kg) which was administered 1 hour after sepsis induction. Plasma was separated from blood collected at 12 hours after sepsis induction. (a–e) The levels of cytokines IL-2, IL-4, IL-1α, TNF-α and IL-10 in plasma were determined by cytometric bead array (f–h) The levels of cytokines IL-6, IFN-γ and IL-1β in plasma were determined by ELISA. Data were expressed as means ± SEM and compared using ANOVA. ^###P < 0.001, compared with sham/control group; *P < 0.05, **P < 0.01, ^***P < 0.001, compared with untreated sepsis group.