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. 2020 Feb 19;10:2947. doi: 10.1038/s41598-020-59716-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Narciclasine prevented liver damage in neonatal septic rats. The neonatal rats were subjected to E. coli sepsis and narciclasine (NC, 0.1, 1 and 3 mg/kg) was administered 1 hour after sepsis induction. Plasma and Livers were collected 12 hours after sepsis induction. (a) The liver histological changes in the presence or absence of narciclasine (NC, 0.1, 1, 3 mg/kg) after H&E staining. The original amplification was x200. (b) The levels of AST and (c) ALT in the plasma were determined using an automated biochemical analyser. (d–g) The levels of cytokines TNF-α, IL-6, IFN-γ and IL-1β in liver homogenates were determined by ELISA. Data were expressed as mean ± SEM and compared using ANOVA. ^###P < 0.001, compared with sham/control group; *P < 0.05, **P < 0.01, ***P < 0.001, compared with untreated sepsis group.