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. 2020 Feb 19;11:908. doi: 10.1038/s41467-020-14652-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b IMR90 cells with or without HMGB2 knockdown treated with CPT were analyzed for TOP1cc levels at the indicated time points by slot blot (a). Fold changes in TOP1cc levels at the indicated time points were quantified (n = 3) (b). c, d IMR90 cells with or without HMGB2 knockdown treated with CPT for 60 min and released from the treatment for 60 or 120 min were analyzed for TOP1cc levels by slot blot (c). Fold changes in TOP1cc levels at the indicated release time points were quantified (n = 3) (d). Data represent mean ± s.e.m. n = 3 biologically independent experiments. P-values were calculated using a two-tailed t test. Source data are provided as a Source Data file.