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. 2020 Feb 19;10:2957. doi: 10.1038/s41598-020-59899-z

Figure 6.

Figure 6

APC knockout in CRC cells impairs Wnt-induced β-catenin destruction complex localization. (a) APC staining in RKO and RKO-APCKO cells. (bd) Representative images of RKO-APCKO cells treated with UB or WB. Representative images and scoring shown for (b,e) β-catenin, (c,f) Axin1, and (d,g) GSK-3β. Data averaged from three independent experiments (n = 25 cells per condition). Error bars, SEM; Statistical analysis by t-test: *P < 0.05; **P < 0.01; ***P < 0.001. Scale bar, 10 μm.