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. 2020 Feb 19;11:956. doi: 10.1038/s41467-020-14750-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b Helical structural elements that show notable conformational changes in the crystal structures of a PPARγ LBD bound to rosiglitazone and TRAP220 ID2 peptide (PDB 6ONJ) in the active conformation and b PPARγ LBD bound to T0070907 and NCoR ID2 peptide (PDB 6ONI) in the repressive conformation. c Structural overlay of the active and repressive conformation PPARγ LBD crystal structures with arrows depicting the movement of the helical structural elements.