Table 1.
A summary of the top ten largest modules in old adipose tissue and their enrichment for GenAge genes, aging DEGs, Disease genes, Differential co-expression genes and the significance for connecting to ARDs as indicated by GeroNet
| Module | #Gene | Function | GenAge | Differential gene | Disease gene | Differential co-expression gene | GeroNet | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Term | FDR | #Overlap | FDR (Rank*) | #Overlap | FDR (Rank*) | #Significant Disease | Geometric mean P (Rank*) | #mean of permutation significant pairs / #significant pairs | FDR (Rank*) | #Significant diseases | Geometric mean FDR (Rank*) | ||
| turquoise | 1299 | mitochondrial matrix | 1.90E-13 | 34 | 5.36E-01 (2) | 97 | 2.84E-40 (1) | 13 | 4.60E-01 (2) | 259.85/1051 | ~ 0 (1) | 125 | 3.62E-49 (1) |
| magenta | 345 | signal peptide | 2.4E-24 | 3 | 1.00E+00 (48) | 31 | 1.49E-13 (2) | 10 | 5.67E-01 (5) | 12.53/306 | ~ 0 (1) | 80 | 1.53E-29 (17) |
| yellow | 691 | signal peptide | 7.36E-06 | 20 | 5.71E-01 (3) | 28 | 1.18E-04 (3) | 10 | 5.45E-01 (4) | 68.68/486 | ~ 0 (1) | 97 | 5.28E-41 (2) |
| maroon | 85 | Oxidoreductase | 3.9E-4 | 2 | 1.00E+00 (30) | 3 | 1.00E-00 (4) | 5 | 8.10E-01 (29) | 0.83/12 | ~ 0 (1) | 18 | 2.30E-17 (34) |
| salmon | 244 | Disulfide bond | 4.5E-3 | 4 | 1.00E+00 (34) | 6 | 1.00E-00 (5) | 7 | 6.14E-01 (7) | 8.89/21 | 2.56E-03 (50) | 62 | 6.41E-25 (23) |
| green | 360 | 8 | 1.00E+00 (15) | 8 | 1.00E-00 (6) | 6 | 6.89#-01 (11) | 27.70/807 | ~ 0 (1) | 67 | 8.97E-34 (10) | ||
| blue | 763 | Cell junction | 7.86E-18 | 10 | 1.00E+00 (46) | 13 | 1.00E-00 (7) | 16 | 5.27E-01 (3) | 89.94/492 | ~ 0 (1) | 98 | 2.37E-32 (11) |
| lightyellow | 175 | 5 | 1.00E+00 (12) | 3 | 1.00E-00 (8) | 5 | 6.99E-01 (13) | 3.73/102 | ~ 0 (1) | 44 | 4.73E-31 (14) | ||
| red3 | 52 | 0 | 1.00E+00 (80) | 1 | 1.00E-00 (9) | 0 | 8.93E-01 (52) | 0.24/0 | 7.48E-01 (75) | 13 | 2.73E-16 (37) | ||
| bisque | 123 | Proto-oncogene | 4.9E-2 | 5 | 9.33E-01 (6) | 2 | 1.00E-00 (10) | 8 | 7.02E-01 (14) | 1.85/6 | 2.45E-02 (54) | 33 | 3.45E-26 (20) |
*Rank was based on the significance of the subnetwork for the corresponding criterion