Table 2.

Summary of the results obtained after meta-analyses.

	Case/trasmitted		Control/untrasmitted
	Events	Total events	Events	Total events	Odd ratio, M-H, Random, 95% CI	Heterogeneity	Test for overall effect
Allele 2
Asian
CC	391	2632	438	2674	0.96 [0.73, 1.27]	Tau² = 0.12; Chi² = 25.00, df = 10 (P = 0.005); I² = 60%	Z = 0.27 (P = 0.79)
TDT	172	849	171	849	1.01 [0.79, 1.28]	Tau² = 0.00; Chi² = 3.96, df = 5 (P = 0.56); I² = 0%	Z = 0.04 (P = 0.96)
European-Caucasian
CC	288	3366	550	6094	1.07 [0.85, 1.33]	Tau² = 0.07; Chi² = 23.08, df = 14 (P = 0.06); I² = 39%	Z = 0.56 (P = 0.57)
TDT	220	1890	248	1889	0.87 [0.71, 1.06]	Tau² = 0.00; Chi² = 10.64, df = 11 (P = 0.47); I² = 0%	Z = 1.40 (P = 0.16)
Middle Eastern
CC	55	616	33	620	1.95 [0.37, 10.29]	Tau² = 2.72; Chi² = 25.05, df = 4 (P < 0.0001); I² = 84%	Z = 0.79 (P = 0.43)
TDT	7	66	6	64	1.15 [0.36, 3.62]	Not applicable	Z = 0.23 (P = 0.82)
South American
CC	96	1254	514	6522	1.15 [0.73, 1.80]	Tau² = 0.10; Chi² = 5.83, df = 3 (P = 0.12); I² = 49%	Z = 0.61 (P = 0.54)
CC	4	56	2	56	2.08 [0.36, 11.83]	Not applicable	Z = 0.82 (P = 0.41)
Allele 4
Asian
CC	2087	2632	2094	2674	1.00 [0.83, 1.21]	Tau² = 0.03; Chi² = 15.60, df = 10 (P = 0.11); I² = 36%	Z = 0.04 (P = 0.97)
TDT	686	950	599	950	1.85 [0.94, 3.63]	Tau² = 0.73; Chi² = 58.64, df = 6 (P < 0.00001); I² = 90%	Z = 1.78 (P = 0.07)
European-Caucasian
CC	2143	3366	4196	6094	0.79 [0.69, 0.91]	Tau² = 0.03; Chi² = 26.67, df = 14 (P = 0.02); I² = 48%	Z = 3.31 (P = 0.0009)
TDT	1020	1890	1054	1889	0.89 [0.73, 1.10]	Tau² = 0.07; Chi² = 24.33, df = 11 (P = 0.01); I² = 55%	Z = 1.08 (P = 0.28)
Middle Eastern
CC	428	684	406	720	1.14 [0.49, 2.66]	Tau² = 0.86; Chi² = 39.51, df = 5 (P < 0.00001); I² = 87%	Z = 0.31 (P = 0.76)
TDT	32	66	27	64	1.29 [0.65, 2.58]	Not applicable	Z = 0.72 (P = 0.47)
South American
CC	848	1426	4148	6636	0.82 [0.65, 1.04]	Tau² = 0.04; Chi² = 9.91, df = 5 (P = 0.08); I² = 50%	Z = 1.66 (P = 0.10)
TDT	41	56	41	56	1.00 [0.43, 2.31]	Not applicable	Z = 0.00 (P = 1.00)
Allele 7
Asian
CC	13	1789	18	2176	0.84 [0.39, 1.80]	Tau² = 0.00; Chi² = 4.90, df = 8 (P = 0.77); I² = 0%	Z = 0.46 (P = 0.65)
TDT	5	265	4	265	1.27 [0.33, 4.87]	Tau² = 0.00; Chi² = 1.02, df = 2 (P = 0.60); I² = 0%	Z = 0.35 (P = 0.72)
European-Caucasian
CC	2020	7618	4279	16506	1.25 [1.07, 1.45]	Tau² = 0.11; Chi² = 104.24, df = 26 (P < 0.00001); I² = 75%	Z = 2.77 (P = 0.006)
TDT	916	3202	720	3201	1.40 [1.23, 1.59]	Tau² = 0.01; Chi² = 23.89, df = 20 (P = 0.25); I² = 16%	Z = 5.09 (P < 0.00001)
Middle Eastern
CC	92	986	124	820	0.61 [0.45, 0.83]	Tau² = 0.00; Chi² = 4.38, df = 5 (P = 0.50); I² = 0%	Z = 3.13 (P = 0.002)
TDT	35	164	28	162	1.34 [0.54, 3.31]	Tau² = 0.26; Chi² = 2.54, df = 1 (P = 0.11); I² = 61%	Z = 0.63 (P = 0.53)
South American
CC	393	1490	1321	6696	1.25 [0.95, 1.65]	Tau² = 0.07; Chi² = 14.05, df = 6 (P = 0.03); I² = 57%	Z = 1.59 (P = 0.11)
TDT	59	313	58	313	1.02 [0.68, 1.53]	Tau² = 0.00; Chi² = 0.86, df = 2 (P = 0.65); I² = 0%	Z = 0.10 (P = 0.92)
Long allele
Asian
CC	72	2952	61	2914	1.22 [0.83, 1.78]	Tau² = 0.01; Chi² = 11.15, df = 11 (P = 0.43); I² = 1%	Z = 1.01 (P = 0.31)
TDT	32	679	20	679	1.49 [0.65, 3.44]	Tau² = 0.32; Chi² = 6.17, df = 4 (P = 0.19); I² = 35%	Z = 0.94 (P = 0.35)
European-Caucasian
CC	848	3560	1072	6311	1.41 [1.19, 1.67]	Tau² = 0.06; Chi² = 32.56, df = 15 (P = 0.005); I² = 54%	Z = 4.04 (P < 0.0001)
TDT	531	1869	448	1864	1.28 [1.05, 1.56]	Tau² = 0.04; Chi² = 17.36, df = 11 (P = 0.10); I² = 37%	Z = 2.49 (P = 0.01)
Middle Eastern
CC	133	976	515	2588	0.62 [0.41, 0.93]	Tau² = 0.13; Chi² = 11.37, df = 5 (P = 0.04); I² = 56%	Z = 2.32 (P = 0.02)
TDT	64	181	90	179	0.63 [0.19, 2.06]	Tau² = 0.62; Chi² = 6.58, df = 1 (P = 0.01); I² = 85%	Z = 0.76 (P = 0.45)
South American
CC	295	1157	1267	5864	1.13 [0.90, 1.43]	Tau² = 0.02; Chi² = 4.82, df = 3 (P = 0.19); I² = 38%	Z = 1.05 (P = 0.29)
TDT	11	56	9	56	1.28 [0.48, 3.37]	Not applicable	Z = 0.49 (P = 0.62)