Table 1.
Flow cytometry analysis of the SMG lymphocytic infiltrated cells from the C57BL/6.NOD-Aec1Aec2 mice (N = 6 mice (3 males and 3 females)/group.
| B cells | T cells | |||
|---|---|---|---|---|
| CD19+ | CD3+ CD4+ | CD4+ IFN-γ+ | CD3+ CD4+ | |
| CD25+ Foxp3+ | ||||
| Lymphocyte % (Mean ± SD) | ||||
| PBS | 0.68 ± 0.51 | 29.79 ± 13.86 | 42.10 ± 12.57 | 1.84 ± 1.16 |
| LDN212854 | 3.22 ± 3.49 | 28.03 ± 10.93 | 18.18 ± 4.07* | 1.00 ± 0.94 |
| LDN193189 | 2.52 ± 2.62 | 28.07 ± 13.57 | 18.02 + 4.75* | 1.98 ± 1.47 |
| P value (t-test) | ||||
| PBS vs LDN212854 | 0.1224 | 0.8525 | 0.0014* | 0.9609 |
| PBS vs LDN193189 | 0.1082 | 0.7609 | 0.0013* | 0.9074 |
| LDN212854 vs LDN193189 | 0.7006 | 0.8803 | 0.9492 | 0.0339 |
*P < 0.05.