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. 2020 Feb 19;10:2990. doi: 10.1038/s41598-020-59999-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ML-265 treatment blocks caspase activation and improves cell survival in a model of apoptosis in vitro. Caspase 8 activity (a), caspase 3/7 activity (b), and cell viability (c) assayed in the presence of DMSO or different concentrations of ML-265 under standard tissue culture conditions or 500 ng/mL FasL and 250 ng/mL hemagglutinin. Cells were pre-treated with ML-265 or DMSO for 2 hours prior to treatment with FasL, and caspase activity and cell viability were measured 8 and 48 hours, respectively, thereafter. n = 8; Mean ± SEM; *p < 0.05; **p < 0.01; ***p < 0.005.