Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 19;10:2990. doi: 10.1038/s41598-020-59999-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

ML-265 treatment decreases apoptosis in experimental retinal detachment. (a) Representative retinal sections of TUNEL-stained photoreceptors (green) after 3 days of retinal detachment. Nuclei of retinal cells are stained with DAPI (blue). INL, inner nuclear layer; ONL, outer nuclear layer. (b) Quantification of TUNEL-positive cells in the ONL. N ≥ 3 eyes per treatment. Caspase 8 activity (c) and caspase 3/7 activity (d) in detached retinas after 3 days as detected by luminescent assay. Caspase activity in the detached retina was normalized to that in the attached control. ML-265 concentrations represent final vitreous concentrations after intravitreal injection. Mean ± SEM; *p < 0.05; **p < 0.01; ***p < 0.005; n = 12 and N = 6 per treatment group.