Figure 4.

Effect of circ‐LARP4 on chemosensitivity of MG63 cells. Effect of circ‐LARP4 on relative cell viability of MG63 cells under different concentrations of cisplatin treatment (A), the IC₅₀ value of cisplatin in blank control group, NC(+) group and Circ‐LARP4(+) group (B), effect of circ‐LARP4 on relative cell viability under different concentrations of methotrexate treatment (C), the IC₅₀ of methotrexate in blank control, NC(+) group and circ‐LARP4(+) group (D), effect of circ‐LARP4 on relative cell viability under different concentrations of doxorubicin treatment (E), and the IC₅₀ value of doxorubicin in blank control, NC(+) group and circ‐LARP4(+) group (F). Comparison was determined by t test. P value <.05 was considered statistically significant. Circ‐LARP4, circular RNA La‐related RNA‐binding protein 4; NC, negative control