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. 2020 Jan 18;10(1):1–14. doi: 10.5500/wjt.v10.i1.1

Table 1.

Major categories of ex vivo machine perfusion therapeutics in liver transplantation

Category Agents
RNAi pathway siRNA
Anti-sense oligonucleotide (Miravirsen)
Defatting cocktail Variable
Vasodilators Prostacyclin
BQ123 and Verapamil
Prostaglandin E1
Others Anti-inflammatory agents
Human liver stem cells extracellular vesicles
δ-opioid agonist (Enkephalin)
NLRP3 inflammasome inhibitor mcc950

RNAi: Ribonucleic acid interference; siRNA: Small interfering ribonucleic acid; NLRP3: Nucleotide-binding domain leucine-rich repeat containing family pyrin domain containing 3.