Figure 1.

Role of Sox10 in differentiation to neural crest (NC)‐specific lineages. Sox10 is required for differentiation of NCs to neurons, melanocytes, and Schwann cells, but downregulated for smooth muscle cell differentiation. Red arrows represent direct binding sites of Sox10 to lineage specific transcription factors. Dashed red lines indicate no evidence for direct binding of Sox10. Green boxes represent extrinsic signals during differentiation. Factors that act synergistically with Sox10 are depicted in blue clouds. Downstream targets of gene regulation by Sox10 are depicted in pink boxes