Figure 1.

Experimental Design for Asexual Blood Stage Specificity Profiling of Antimalarials and Profiles of Reference Drugs

(A) Synchronized parasites were exposed for 8 h at the stages indicated. Survival at 60 h post-invasion was assessed by flow cytometry.

(B) Unique stage specificity profiles of chloroquine, dihydroartemisinin, and KAI407. Bar plots indicate the IC₅₀^8h when parasites were exposed only during the early ring, late ring, early trophozoite, late trophozoite, or schizont stage, with error bars showing the standard error of the mean based on at least three independent repeats. KAI407, a PI4K inhibitor. All data are available in Table S1.