Table 5.
Isolate code | Lysozyme (30 μg/mL) | Ceftazidime (50 × MIC) | Cefepime (50 × MIC) | Lysozyme (30 μg/mL) + ceftazidime (50 × MIC) | Lysozyme (30 μg/mL) + cefepime (50 × MIC) |
---|---|---|---|---|---|
B3 | 18.4 | 60.4 | 87.5 | 69.9 | 83.7 |
B5 | 11.9 | 36.9 | 44.8 | 39.4 | 40.7 |
Cl1 | 5.3 | 8.9 | 13.6 | 9.2 | 2.6 |
Cl3 | 30.6 | 50.7 | 76.4 | 65 | 89.5 |
Cl4 | 14 | 21.5 | 30.5 | 22.9 | 38.6 |
E4 | 44.8 | 68.1 | 86.7 | 83 | 95.7 |
S13 | 4.3 | 22.4 | 10.9 | 7.8 | 19.7 |
U7 | 12.9 | 21.2 | 37.1 | 32 | 46.8 |
U16 | 1.5 | 5.6 | 25.5 | 18.3 | 57.2 |
U19 | 7.4 | 11 | 14.4 | 12.5 | 17.4 |
U25 | 5.9 | 45.5 | 47.2 | 43.4 | 46.2 |
U30 | 10.8 | 32.5 | 45.1 | 36.9 | 50.7 |
Uc2 | 13.6 | 35.3 | 44.8 | 41.8 | 47.3 |
W10 | 12 | 49.1 | 89.6 | 86 | 94.8 |
W12 | 8.2 | 10.4 | 15 | 12.4 | 17.9 |
W14 | 35.9 | 45.8 | 38.8 | 48.9 | 41.5 |
Average ± SE | 14.8 ± 0.75 | 32.8 ± 1.2 | 44.2 ± 1.7 | 39.3 ± 1.61 | 49.3 ± 1.79 |
The percentage of biofilm reduction for each isolate was determined after normalization to negative controls that were not treated with lysozyme or antibiotics. Averages are the means ± standard errors of the means from four independent experiments. B: burn; Cl: contact lens; E: eye; S: sputum; U: urine; Uc: urinary catheter; W: wound.