Skip to main content
. 2019 Oct 9;117(10):1963–1980. doi: 10.1016/j.bpj.2019.10.003

Figure 5.

Figure 5

cAMP and PKA time course and PDE1 and PDE4 phosphorylation by PKA predicted by our model: (A) cAMP dynamics predicted by our model show mainly minute-scale oscillations and leaky oscillations on the second scale shown in the figure inset. (B) PKA dynamics predicted by our model shows only minute-scale oscillations and no second-scale oscillations (figure inset). (C) Phosphorylation of PDE1 by PKA and formation of phosphorylated PDE1 (PDE1P) that oscillates only on the minute scale. (D) PDE4 and phosphorylated PDE4 (PDE4P) formed by PKA that is indirectly affected by calcium show almost neither of the second- or minute-scale oscillations. To see this figure in color, go online.