Table 1.

Summary of 3 included studies.

Study	Participants	Immobilization model/period	Intervention	Comparison	Outcome measures
Takarada et al. (2000)27	Patients submitted to ACL reconstruction surgery n = 16 (8 males, 8 females) Age: approximately 21–25 years Thigh girth: not informed	Knee brace/2 weeks	BFRP: 5 sets of 5 min of occlusion and 3 min of free flow Frequency: twice a day between 3rd and 14th day after the surgery (11 days/22 sessions) OCS: Width (90 mm); Length (700 mm) Placement: Proximal end of the thigh (100 mm below the hip joint) Occlusive pressure: mean pressure of 238 mmHg	Sham: occlusion cuff without inflation	Muscular atrophy: cross-sectional area
Kubota et al. (2008)28	Healthy n = 11 males Age: approximately 21–25 years Thigh girth: approximately 45–51 cm	Left ankle joint immobilization by cast and not weight-bearing/2 weeks	BFRP: 5 sets of 5 min of occlusion and 3 min of free flow Frequency: Twice a day for 2 weeks (14 days/28 sessions) OCS: Width (77 mm); Length (770 mm) Placement: Proximal end of the thigh Occlusive pressure: 200 mmHg	Control: without intervention	Muscle strength: isokinetic (eccentric and concentric) and isometric torque Muscular atrophy: thigh girth
Kubota et al. (2011)24	Healthy n = 11 males for muscle strength measures and n = 10 males for thigh girth measures Age: approximately 21–24 years Thigh girth: approximately 48–52 cm	Left ankle joint immobilization by cast and not weight-bearing/2 weeks	BFRP: 5 sets of 5 min of occlusion and 3 min of free flow Frequency: Twice a day for 2 weeks (14 days/28 sessions) OCS: Width (77 mm); Length (770 mm) Placement: Proximal end of the thigh Occlusive pressure: 50 mmHg	Control: without intervention	Muscle Strength: isokinetic (eccentric and concentric) and isometric torque Muscular Atrophy: thigh girth

Abbreviations: ACL = anterior cruciate ligament; BFRP = blood flow restriction protocol; OCS = occlusion cuff settings.