Fig. 2.

Luminal A (a) and basal (b) TF-TF network. A directed edge from TF A to TF B means that A binds to B according to ChIP-seq experiment of A in ENCODE database. Blue nodes: ChIP’ed TFs. Red nodes: the TF subset of the subtype’s ESGs which are targeted by the ChIP’ed TFs. TF target genes (red nodes) are partitioned into groups based on different upstream binding factors (blue nodes), and are involved in distinct biological processes (circled and process names in red). In addition to this network, we show an extended TF-target network as a heatmap in Supplementary Figures S3 and S4