Table 4.

Association between phthalate biomarkers and miRNAs in fibroid tissue.^a

Phthalate	miRNA name	Estimateb	95% CI	P-value	FDR q-valuec
MEP	miR-429	−0.60	[–0.93, –0.27]	.0006	0.24
	miR-200b-3p	−0.46	[–0.77, –0.16]	.004	0.53
	miR-548c-5p	−0.29	[–0.47, –0.10]	.004	0.53
MnBP	miR-338-5p	1.55	[0.53, 2.58]	.004	0.73
MHBP	miR-10a-5p	0.76	[0.40, 1.11]	.0001	0.05
	miR-30a-3p	0.65	[0.25, 1.06]	.002	0.40
	miR-142-5p	0.70	[0.24, 1.15]	.004	0.40
	miR-142-3p	0.75	[0.25, 1.25]	.004	0.40
MHiBP	miR-10a-5p	0.58	[0.23, 0.93]	.002	0.61
MCPP	miR-154-5p	1.13	[0.53, 1.72]	.0004	0.17
	miR-7-5p	0.54	[0.19, 0.90]	.004	0.54
MCOP	miR-21-3p	−0.29	[–0.47, –0.12]	.002	0.35
	miR-582-3p	−0.28	[–0.45, –0.11]	.002	0.35
	miR-449b-5p	0.37	[0.13, 0.62]	.004	0.46
MCNP	miR-590-3p	0.70	[0.27, 1.14]	.002	0.87
MEHP	miR-635	0.70	[0.27, 1.14]	.002	0.67
MEHHP	miR-577	1.06	[0.53, 1.59]	.0003	0.10
	miR-1179	0.88	[0.36, 1.40]	.002	0.27
	miR-7-2-3p	0.61	[0.25, 0.98]	.002	0.23
	miR-192-3p	0.48	[0.18, 0.78]	.003	0.28
	miR-7-5p	0.65	[0.22, 1.09]	.004	0.32
MEOHP	miR-1179	0.85	[0.37, 1.33]	.0009	0.27
	miR-577	0.88	[0.36, 1.40]	.002	0.27
	miR-572	−0.50	[–0.81, –0.19]	.002	0.27
	miR-26b-3p	0.47	[0.16, 0.77]	.004	0.29
	miR-7-5p	0.62	[0.22, 1.03]	.004	0.29
MECPP	miR-577	1.01	[0.41, 1.62]	.002	0.61
	miR-93-5p	0.39	[0.13, 0.65]	.004	0.62
ΣDEHP	miR-577	1.13	[0.53, 1.72]	.0004	0.17
	miR-1179	0.92	[0.33, 1.51]	.003	0.42
ΣAA phthalates	miR-7-5p	0.80	[0.31, 1.29]	.002	0.35
	miR-7-2-3p	0.68	[0.26, 1.10]	.003	0.35
	miR-577	0.97	[0.36, 1.59]	.003	0.35
	miR-572	−0.56	[–0.93, –0.20]	.004	0.35

Abbreviations: AA, anti-androgenic; DEHP, di(2-ethylhexyl) phthalate; MCNP, monocarboxynonyl phthalate, MCOP, monocarboxyoctyl phthalate; MCPP, mono(3-carboxypropyl) phthalate; MECPP, mono(2-ethyl-5-carboxypentyl) phthalate; MEHP, mono(2-ethylhexyl) phthalate; MEHHP, mono(2-ethyl-5-hydroxyhexyl) phthalate; MEOHP, mono(2-ethyl-5-oxohexyl) phthalate; MEP, mono-ethyl phthalate; MHBP, mono-hydroxybutyl phthalate; miRNAs, microRNAs; MnBP, mono-n-butyl phthalate.

^aAssociation at P < .005 are shown. The full list of phthalate-miRNA associations significant at P < .05 are shown in Supplemental Table S2. All associations are adjusted for age, BMI, and race/ethnicity. Lower ΔC_q indicates higher relative miRNA expression.

^bFor every 1-unit increase in the natural-log phthalate metabolite concentration, there is an effect size increase/decrease in the miRNA ΔC_q.

^cFDR q-values are adjusted for multiple testing for the 388 miRNAs but not for the number of phthalate biomarkers.