Table 3.
Differences in RHC-derived measures of RV function in prevalent PAH patients with mild and severe disease.
| Prevalent mild PAH (n = 11) | Prevalent severe PAH (n = 10) | |
|---|---|---|
| RV systolic function | ||
| Max dP/dt (mmHg/s) | 383 ± 150 | 750 ± 293* |
| Contractile Index (L/s) | 8.41 ± 2.76 | 8.07 ± 2.24 |
| Ees (mmHg/mL) | 0.73 ± 0.47 | 1.37 ± 0.76* |
| RV afterload/work | ||
| Ea (mmHg/mL) | 0.57 ± 0.17 | 1.35 ± 0.40* |
| Stroke work (g/m/beat/m2) | 15.59 ± 3.38 | 20.58 ± 7.16 |
| RV-PA coupling | ||
| Ees/Ea | 1.36 ± 0.82 | 0.98 ± 0.40 |
| RV diastolic function | ||
| Min dP/dt (mmHg/s) | −425 ± 134 | −756 ± 225* |
| RHC-derived MPI | 0.34 ± 0.12 | 0.49 ± 0.21 |
| RV diastolic stiffness coefficient (mL–1) | 0.029 ± 0.011 | 0.043 ± 0.012* |
| Eed (mmHg/mL) | 0.33 ± 0.31 | 0.83 ± 0.37* |
*
P < 0.05 vs. prevalent mild PAH.
Ees, end-systolic elastance; Ea, arterial elastance; MPI, Myocardial Performance Index; Eed, end-diastolic elastance.