Table 2.
Resting (supine legs up) and peak exercise hemodynamics.
| No lung disease (n = 35) | Lung disease (n = 21) | p Values | |
|---|---|---|---|
| Resting (supine legs up) hemodynamics | |||
| mPAP (mmHg) | 20 (17–23.7) | 20.3 (18–27.7) | 0.36 |
| PAWP (mmHg) | 10.5 (7–13) | 10 (6–13) | 0.59 |
| TPR (WU) | 3.1 (2.5–4.1) | 3.7 (2.7–4.5) | 0.35 |
| PVR (WU) | 1.5 (1.1–1.9) | 1.6 (1.3–2.5) | 0.19 |
| PAC (mL/mmHg) | 3.8 (3.3–5.1) | 2.9 (2.4–3.5) | 0.004 |
| SpO2 (%) | 98 (96.5–100) | 98 (96.5–99) | >0.9 |
| O2 (LPM) | 0 (0–0) | 0 (0–3) | 0.06 |
| Peak hemodynamics | |||
| mPAP (mmHg) | 29.7 (22.7–35) | 34.7 (30.3–41) | 0.03 |
| PAWP (mmHg) | 16 (11–21) | 15 (11–19) | 0.67 |
| TPR (WU) | 2.8 (2.0–3.3) | 3.6 (2.3–4.5) | 0.05 |
| PVR (WU) | 1.3 (0.9–1.7) | 2.3 (1.5–2.6) | 0.01 |
| PAC (mL/mmHg) | 2.4 (2.1–3.3) | 2.2 (1.6–2.6) | 0.04 |
| Alpha (%/mmHg) | 1.1 (0.7–1.6) | 0.7 (0.5–1.1) | 0.05 |
| Slope of mPAP/CO (mmHg/L/min) | 1.9 (0.9–2.6) | 3.0 (1.2–3.7) | 0.06 |
| CO (L/min) | 11.3 (9.1–12.6) | 10.5 (8.6–12.2) | 0.61 |
| CI (L/min/m2) | 6.1 (4.8–6.7) | 5.7 (4.8–6.1) | 0.42 |
| Stroke volume (mL) | 93 (78–108) | 94 (78–118) | 0.52 |
| PA saturation (%) | 71 (65–74) | 69 (66–71) | 0.35 |
| SpO2 (%) | 97 (95–98) | 93 (90.5–96) | 0.02 |
| O2 (LPM) | 0 (0–0) | 0 (0–4) | 0.03 |
Pairwise comparisons between patients with and without parenchymal lung disease. Values are indicated as median with interquartile range (IQR).
mPAP: mean pulmonary artery pressure; PAWP: pulmonary arterial wedge pressure; TPR: total peripheral resistance; PVR: pulmonary vascular resistance; PAC: pulmonary arterial compliance; CO: cardiac output; CI: cardiac index; PA: pulmonary artery.