Table 3.
Resting hemodynamics stratified by parenchymal lung disease.
| No lung disease |
p Values | Lung disease |
p Values | |||
|---|---|---|---|---|---|---|
| DLco ≥ 73% (n = 11) | DLco < 73% (n = 21) | DLco ≥ 46% (n = 8) | DLco < 46% (n = 9) | |||
| FVC (%) | 105 (66–116) | 86 (72–96) | 0.20 | 72 (60–91) | 81 (75–107) | 0.15 |
| FEV1 (%) | 111 (67–123) | 89 (71–98) | 0.16 | 69 (48–81) | 73 (37–83) | 0.82 |
| RAP (mmHg) | 7 (3–8) | 6 (3–7) | 0.86 | 4.5 (2.5–7) | 6 (3–6) | 0.81 |
| PASP (mmHg) | 29 (25–38) | 35 (30–41) | 0.10 | 37 (30–39.5) | 48 (42–50) | 0.04 |
| PADP (mmHg) | 11 (9–12) | 15 (11–17) | 0.02 | 9 (6.5–12) | 12 (11–17) | 0.07 |
| mPAP (mmHg) | 18 (14.3–20) | 21.3 (18.3–24.3) | 0.04 | 18.3 (14.3–21.2) | 23.3 (19–30) | 0.03 |
| PAWP (mmHg) | 10 (7–13) | 11 (9–13) | 0.75 | 9.5 (6–14.5) | 10 (6–12) | 0.67 |
| TPR (WU) | 3.1 (2.1–3.3) | 3.2 (2.6–4.3) | 0.14 | 2.9 (2.3–3.5) | 4.5 (3.7–5.6) | 0.02 |
| PVR (WU) | 1.2 (0.6–1.6) | 1.6 (1.3–2.2) | 0.08 | 1.2 (0.9–1.5) | 2.5 (1.9–3.7) | 0.008 |
| PAC (mL/mm Hg) | 5.0 (3.4–5.2) | 3.8 (3.2–4.8) | 0.42 | 3.5 (2.7–4.1) | 2.8 (2.2–3.1) | 0.10 |
| TPG (mm Hg) | 8.7 (8–12) | 11.3 (11–16) | 0.09 | 10.2 (6.8–14) | 17 (15–23) | 0.007 |
| Time constant calculated (s) | 0.37 (0.18–0.42) | 0.36 (0.34–0.48) | 0.26 | 0.32 (0.15–0.32) | 0.31 (0.25–0.68) | 0.29 |
| PA saturation (%) | 72 (67–78) | 69 (64–73) | 0.43 | 69 (67–70) | 69 (66–71) | 0.85 |
| PA pulse pressure (mm Hg) | 21 (16–27) | 22 (19–25) | 0.62 | 27.5 (23.5–28) | 31 (24–37) | 0.44 |
| CO (L/min) | 6.1 (5.3–6.8) | 6.3 (4.9–7.3) | 0.81 | 6.5 (5.7–7.0) | 5.9 (5.2–6.5) | 0.25 |
| CI (L/min/m2) | 3.3 (2.8–3.7) | 3.3 (2.4–3.8) | 0.40 | 3.1 (2.7–3.5) | 3.0 (2.7–3.2) | 0.67 |
| Stroke volume (mL) | 104.8 (85.3–105.4) | 80.7 (70.5–95.6) | 0.05 | 95.3 (71.3–109.7) | 75 (67.5–83.9) | 0.25 |
| SpO2 (%) | 98 (97.5–99.5) | 98.5 (96–100) | 0.78 | 98 (97–99) | 98 (96–99) | 0.68 |
| O2 (LPM) | 0 (0–0) | 0 (0–0) | >0.9 | 0 (0–0) | 2 (0–3) | 0.35 |
FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; RAP: right atrial pressure; PASP: pulmonary artery systolic pressure; PADP: pulmonary artery diastolic pressure; mPAP: mean pulmonary artery pressure; PAWP: pulmonary arterial wedge pressure; TPR: total peripheral resistance; PVR: pulmonary vascular resistance; PAC: pulmonary arterial compliance; TPG: transpulmonary gradient; PA: pulmonary artery; CO: cardiac output; CI: cardiac index.