Table 2.
Top differentially methylated probes from a comparison of diabetic vs non-diabetic samples
| Gene ID | cg ID | Gene name | Function/pathway | Associated disorders/diseases | Gene location | Mean difference (M value) | Adjusted p value |
|---|---|---|---|---|---|---|---|
| CCDC110 | cg07221855 | Coiled-coil domain-containing protein 110 | Body | − 0.484995 | 0.000916 | ||
| KALRN | cg20807374 | Kalirin | Signaling receptor binding; promotes the exchange of GDP by GTP; activates specific Rho GTPase family members; regulates neuronal shape, growth, and plasticity; interacts with the huntingtin-associated protein 1 | Huntington’s disease, coronary heart disease | Body | − 0.608775 | 0.002236 |
| PAG1 | cg01108434 | Phosphoprotein associated with glycosphingolipid-enriched microdomains | Type III transmembrane adaptor protein; binds to tyrosine kinase csk protein; regulation of T cell activation | 5′UTR | − 0.584836 | 0.002785 | |
| GNRH1 | cg25710809 | Progonadoliberin-1 | Hormone receptor binding/activity; signaling receptor activity; gonadotropin-releasing hormone receptor pathway | Hypo-gonadotropic hypogonadism | TSS1500 | − 0.511411 | 0.002785 |
| SLC2A9 | cg26210521 | Solute carrier family 2, facilitated glucose transporter member 9 | Glucose transporter 9 (GLUT9); located in proximal tubules, reabsorption of nutrients, water, and other into the blood and excretion into the urine; reabsorbing and excreting glucose | Renal hypouricemia, gout | Body | − 0.519168 | 0.004015 |
| CSRP2BP | cg19354792 | Cysteine-rich protein 2-binding protein | Histone acetyltransferase activity; zinc finger protein adapters, acetyltransferase domain | Cytochrome c oxidase deficiency | Body; TSS1500 | − 0.463411 | 0.004738 |
| HIVEP1 | cg14398337 | Human immunodeficiency virus type I enhancer binding protein 1/zinc finger protein 40 | Transcription factor belonging, enhancer elements of several viral promoters, binds to a sequence motif, transcriptional regulation of both viral and cellular genes | OCD, ADHD | Body | − 0.427399 | 0.006924 |
| RALGDS | cg10509965 | RAL guanine nucleotide dissociation stimulator | Guanyl-nucleotide exchange factor, exchange of GDP and GTP in a G-protein; enzyme regulator activity; G-protein coupled receptor signaling pathway; MAPK cascade; cell cycle | Body | − 0.300234 | 0.018452 | |
| DHX37 | cg04226314 | ATP-dependent RNA helicase DHX37 related | RNA helicase; ATP-dependent helicase activity; catalytic activity, acting on RNA; rRNA processing, gene expression; DEAD box, embryogenesis, spermatogenesis, and cellular growth and division | Body | − 0.504887 | 0.030713 | |
| SCNN1D | cg12120973 | Amiloride-sensitive sodium channel subunit delta | Ion channel; cation transport; regulation of biological processes; sensory perception of pain and taste; transport of glucose and other sugars, bile salts and organic acids, metal ions, and amine compounds | 5′UTR; 1stExon; Body | − 0.430032 | 0.034144 |