Table 1.
CHIKV amino acid mutations associated with phenotype change in vector
| Protein | Amino acid substitution | Phenotype | Asian lineage | Asian lineage Ecuador cluster only |
|---|---|---|---|---|
| E1 | A226V | Enhanced infection of Ae .albopictus [27] | A | A |
| E1 | A98T | Restricts positive selection of the Ae. albopictus-adaptive E1-A226V substitution [28, 29] | T | T |
| E1 | K211E | Enhanced fitness in Ae aegypti in background of E1-226A [30] | E | E |
| E2 | V264A | V | V | |
| E2 | K233E/Q | Enhanced infection of Ae. albopictus [28] | K | K |
| E2 | K234E | Enhanced infection of Ae. albopictus [28] | K | K |
| E2 | K252Q | Enhanced infection of Ae. albopictus – secondary mutation [28] | K | K |
| E2 | R198Q | Enhanced infection of Ae. albopictus, synergistic with E3-18F in background of E1-226V [28] | R | R |
| E2 | L210Q | Enhanced infection of Ae. albopictus, synergistic with E3:18F in background of E1:226V [28, 31] | L | L |
| E3 | S18F | Enhanced infection of Ae. albopictus, synergistic with E2:R198Q [28] | S, F | S |
Bold and underline - vector adaptive residues