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. 2020 Feb 19;20:134. doi: 10.1186/s12885-020-6617-x

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — MRI images shown for both anatomical T2-weighted scan, DWI scan from shortest b-value, and overlay of anatomical image and ADC-map. Depicted is one mouse from each group in both models. The T2-weighted anatomical sequence was performed on Bruker 7 T preclinical MRI system using the following parameters; TR/TE. 2500/35 milliseconds, image size: 256 × 256, Field of view (FOV): 30 × 30 mm, averages: 2, slice thickness: 0.7 mm, and scan time 2 min 40 s. Diffusion-weighted scan sequence was performed using the following parameters; TR/TE: 550/24 milliseconds, image size: 96 × 96, FOV: 30 × 30 mm, averages: 6, segments: 6, slice thickness: 0.7 mm, b-values: 0, 100, 200, 600, 1000, 1500, 2000, and scan time 2 min 18 s