Table 2. Antiviral intervention initiated in the second trimester compared to the third trimester in maternal HBV-DNA (log10) before treatment.

Study or subgroup	Second Trimester			Third Trimester			Weight	Mean Difference	Mean Difference
	Mean	SD	Total	Mean	SD	Total		IV, Fixed, 95% CI	IV, Fixed, 95% CI
Han et al.23	7.91	0.75	257	7.83	0.775	105	29.3%	0.08 [-0.09, 0.25]
Hu et al.20	8.25	1.22	30	8.13	1.41	30	2.0%	0.12 [-0.55, 0.79]
Liu et al.22	7.67	0.79	24	7.46	0.73	32	8.0%	0.21 [-0.12, 0.54]
Pan et al.25	7.22	0.61	66	7.26	0.55	94	26.2%	-0.04 [-0.22, 0.14]
Wang et al.24	7.53	0.81	21	7.53	0.81	27	4.2%	0.00 [-0.46, 0.46]
Wang et al.21 (1)	7.74	1.8	20	7.93	2.06	20	0.6%	-0.19 [-1.39, 1.01]
Wang et al.21 (2)	7.74	1.8	20	8.01	1.92	20	0.7%	-0.27 [-1.42, 0.88]
Wang et al.21 (3)	7.74	1.8	20	7.47	1.87	20	0.7%	0.27 [-0.87, 1.41]
Wang et al.21 (4)	7.96	2.07	20	7.93	2.06	20	0.5%	0.03 [-1.25, 1.31]
Wang et al. 21 (5)	7.96	2.07	20	8.01	1.92	20	0.6%	-0.05 [-1.29, 1.19]
Wang et al.21 (6)	7.96	2.07	20	7.47	1.87	20	0.6%	0.49 [-0.73, 1.71]
Wang et al.18 (1)	7.76	1.76	20	7.98	1.9	20	0.7%	-0.22 [-1.36, 0.92]
Wang et al.18 (2)	7.76	1.76	20	7.96	1.87	20	0.7%	-0.20 [-1.33, 0.93]
Wang et al.18 (3)	7.76	1.76	20	7.4	1.65	20	0.8%	0.36 [-0.70, 1.42]
Wang et al. 18 (4)	7.89	1.91	20	7.98	1.9	20	0.6%	-0.09 [-1.27, 1.09]
Wang et al.18 (5)	7.89	1.91	20	7.96	1.87	20	0.6%	-0.07 [-1.24, 1.10]
Wang et al.18 (6)	7.89	1.91	20	7.4	1.65	20	0.7%	0.49 [-0.62, 1.60]
Yin and Wang19	8.68	1.16	74	8.6	1.26	149	8.0%	0.08 [-0.25, 0.41]
Zhou et al.17	7.52	0.63	49	7.43	0.72	64	14.3%	0.09 [-0.16, 0.34]
Total (95% CI)			761			741	100%	0.06 [-0.04, 0.15]
Heterogeneity: Chi2 = 4.67; df = 18 (P = 1.00); I2 = 0%
Test for overall effect: Z = 1.15 (P = 0.25)