Table 3. Antiviral intervention initiated in the second trimester compared to the third trimester in maternal HBV-DNA (log10) prior to delivery.

Study or subgroup	Second Trimester			Third Trimester			Weight	Mean Difference	Mean Difference
	Mean	SD	Total	Mean	SD	Total		IV,Randon,95% CI	IV,Random,95% CI
Han et al.23	2.5	1.8	257	3.3	1.6	105	7.8%	-0.80 [-1.18, -0.42]
Hu et al.20	6.3	1.94	30	6.42	2.0	30	5.5%	-0.12 [-1.12, 0.88]
Pan et al.25	4.12	1.02	66	4.68	0.9	94	8.0%	-0.56 [-0.87, -0.25]
Wang et al.21 (1)	3.38	1.45	20	4.16	1.6	20	5.7%	-0.78 [-1.73, 0.17]
Wang et al.21 (2)	3.38	1.45	20	5.45	1.87	20	5.4%	-2.07 [-3.11, -1.03]
Wang et al.21 (3)	3.38	1.45	20	5.98	1.67	20	5.6%	-2.60 [-3.57, -1.63]
Wang et al.21 (4)	3.68	1.42	20	4.16	1.6	20	5.8%	-0.48 [-1.42, 0.46]
Wang et al.21 (5)	3.68	1.42	20	5.45	1.87	20	5.4%	-1.77 [-2.80, -0.74]
Wang et al.21 (6)	3.68	1.42	20	5.98	1.67	20	5.7%	-2.30 [-3.26, -1.34]
Wang et al.18 (1)	2.97	1.11	20	3.38	1.34	20	6.4%	-0.41 [-1.17, 0.35]
Wang et al.18 (2)	2.97	1.11	20	4.83	1.63	20	6.0%	-1.86 [-2.72, -1.00]
Wang et al.18 (3)	2.97	1.11	20	5.65	1.45	20	6.3%	-2.68 [-3.48, -1.88]
Wang et al.18 (4)	3.22	1.23	20	3.38	1.34	20	6.3%	-0.16 [-0.96, 0.64]
Wang et al. 18 (5)	3.22	1.23	20	4.83	1.63	20	5.9%	-1.61 [-2.50, -0.72]
Wang et al.18 (6)	3.22	1.23	20	5.65	1.45	20	6.2%	-2.43 [-3.26, -1.60]
Yin and Wang19	3.57	1.23	74	4.05	1.28	149	7.9%	-0.48 [-0.83, -0.13]
Total (95% CI)			667			618	100%	-1.27 [-1.67, -0.87]
Heterogeneity: Tau2=0.51; Chi2=85.3; df=15(P<0.00001); I2=82%
Test for overall effect :Z=6.18(P<0.00001)