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. 2020 Feb 14;62:e13. doi: 10.1590/S1678-9946202062013

Table 6. Forest plot on the rate of mother-to-child hepatitis B virus transmission (subgroup analyses according to different starting times).

Study or Subgroup Second Trimester Third Trimester Weight Risk Ratio Risk Ratio
Events Total Events Total M-H,Fixed,95% CI M-H,Fixed,95% CI
6.1 14 w VS 28 w graphic file with name 1678-9946-rimtsp-62-S1678-9946202062013-ingf05.jpg
Hu et al.20 0 30 1 30 17.9% 0.33 [0.01, 7.87]
Subtotal (95% CI)   30   30 17.9% 0.33 [0.01, 7.87]
Total events 0   1      
Heterogeneity: Not applicable
Test for overall effect: Z = 0.68 (P = 0.50)
6.2 20 w VS 28 W
Zhou et al.17 0 49 5 65 56.5% 0.12 [0.01, 2.12]
Wang et al.21 (1) 0 20 0 20   Not estimable
Wang et al.18 (1) 0 20 0 20   Not estimable
Subtotal (95% CI)   89   105 56.5% 0.12 [0.01, 2.12]
Total events 0   5      
Heterogeneity: Not applicable
Test for overall effect: Z = 1.45 (P = 0.15)
6.3 20 w VS 32 w
Wang et al.18 (2) 0 20 0 20   Not estimable
Wang et al.21 (2) 0 20 0 20   Not estimable
Subtotal (95% CI)   40   40   Not estimable
Total events 0   0      
Heterogeneity: Not applicable
Test for overall effect: Not applicable
6.4 20 w VS 36 w
Wang et al.21 (3) 0 20 0 20   Not estimable
Wang et al.18 (3) 0 20 0 20   Not estimable
Subtotal (95% CI)   40   40   Not estimable
Total events 0   0      
Heterogeneity: Not applicable
Test for overall effect: Not applicable
6.5 24 w VS 28 w
Wang et al.24 0 21 0 27   Not estimable
Yin and Wang19 0 74 0 149   Not estimable
Wang et al.21 (4) 0 20 0 20   Not estimable
Wang et al.18 (4) 0 20 0 20   Not estimable
Subtotal (95% CI)   135   216   Not estimable
Total events 0   0      
Heterogeneity: Not applicable
Test for overall effect: Not applicable
6.6 24 w VS 32 w
Wang et al.18 (5) 0 20 0 20   Not estimable
Wang et al.21 (5) 0 20 0 20   Not estimable
Subtotal (95% CI)   40   40   Not estimable
Total events 0   0      
Heterogeneity: Not applicable
Test for overall effect: Not applicable
6.7 24 w VS 36 w
Wang et al.18 (6) 0 20 0 20   Not estimable
Wang et al.21 (6) 0 20 0 20   Not estimable
Subtotal (95% CI)   40   40   Not estimable
Total events 0   0      
Heterogeneity: Not applicable
Test for overall effect: Not applicable
6.8 the second trimester and the third trimester
Liu et al.22 0 24 2 32 25.7% 0.26 [0.01, 5.26]
Pan et al.25 0 66 0 94   Not estimable
Han et al.23 0 257 0 105   Not estimable
Subtotal (95% CI)   347   231 25.7% 0.26 [0.01, 5.26]
Total events 0   2      
Heterogeneity: Not applicable
Test for overall effect: Z = 0.87 (P = 0.38)
Total (95% CI)   761   742 100% 0.20 [0.03, 1.09]
Total events 0   8      
Heterogeneity: Chi2 = 0.26; df = 2 (P = 0.88); I2 = 0%
Test for overall effect: Z = 1.86 (P = 0.06)
Test for subgroup differences: Chi2 = 0.25; df = 2 (P = 0.88) ; I2 = 0%