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. 2020 Feb 14;62:e13. doi: 10.1590/S1678-9946202062013

Table 7. Forest plot on the rate of mother-to-child hepatitis B virus transmission (HBsAg seropositivity or HBV-DNA seropositivity).

Study or Subgroup Second Trimester Third Trimester Weight Risk Ratio Risk Ratio
Events Total Events Total M-H,Fixed,95% CI M-H,Fixed,95% CI
7.1 HBsAg seropositivity   graphic file with name 1678-9946-rimtsp-62-S1678-9946202062013-ingf06.jpg
4.4.1 HBsAg seropositivity  
Han et al.23 0 257 0 105   Not estimable
Liu et al.22 0 24 2 32 21.6% 0.26 [0.01, 5.26]
Pan et al.25 0 66 0 94   Not estimable
Wang et al.24 0 21 0 27   Not estimable
Wang et al.21 (1) 0 20 0 20   Not estimable
Wang et al.21 (2) 0 20 0 20   Not estimable
Wang et al.21 (3) 0 20 0 20   Not estimable
Wang et al.21 (4) 0 20 0 20   Not estimable
Wang et al.21 (5) 0 20 0 20   Not estimable
Wang et al.21 (6) 0 20 0 20   Not estimable
Wang et al.18 (1) 0 20 0 20   Not estimable
Wang et al. 18 (2) 0 20 0 20   Not estimable
Wang et al.18 (3) 0 20 0 20   Not estimable
Wang et al.18 (4) 0 20 0 20   Not estimable
Wang et al.18 (5) 0 20 0 20   Not estimable
Wang et al.18 (6) 0 20 0 20   Not estimable
Yin and Wang19 0 74 0 149   Not estimable
Zhou et al.17 0 49 5 64 47.9% 0.12 [0.01, 2.09]
Subtotal (95% CI)   731   711 69.5% 0.16 [0.02, 1.28]
Total events            
Heterogeneity: Chi2 = 0.15; df = 1 (P = 0.70); I2 = 0%
Test for overall effect: Z = 1.73 (P = 0.08)
7.2 HBV DNA seropositivity  
Han et al.23 0 257 0 105   Not estimable
Liu et al.22 0 24 0 32   Not estimable
Pan et al.25 0 66 0 94   Not estimable
Wang et al.24 0 21 0 27   Not estimable
Wang et al.21 (1) 0 20 0 20   Not estimable
Wang et al.21 (2) 0 20 0 20   Not estimable
Wang et al.21 (3) 0 20 0 20   Not estimable
Wang et al.21 (4) 0 20 0 20   Not estimable
Wang et al.21 (5) 0 20 0 20   Not estimable
Wang et al.21 (6) 0 20 0 20   Not estimable
Wang et al.18 (1) 0 20 0 20   Not estimable
Wang et al.18 (2) 0 20 0 20   Not estimable
Wang et al.18 (3) 0 20 0 20   Not estimable
Wang et al.18 (4) 0 20 0 20   Not estimable
Wang et al.18 (5) 0 20 0 20   Not estimable
Wang et al.18 (6) 0 20 0 20   Not estimable
Zhou et al.17 0 49 3 64 30.5% 0.19 [0.01, 3.51]
Subtotal (95% CI)   657   562 30.5% 0.19 [0.01, 3.51]
Total events 0   3      
Heterogeneity: Not applicable
Test for overall effect: Z = 1.12 (P = 0.26)
Total (95% CI)   1,388   1,273 100% 0.17 [0.03, 0.92]
Total events 0   10      
Heterogeneity: Chi2 = 0.15; df = 2 (P = 0.93); I2 = 0%
Test for overall effect: Z = 2.06 (P = 0.04)
Test for subgroup differences: Chi2 = 0.00; df = 1 (P = 0.94) ; I2 = 0%