Table 2.
Biomarkers of hemolysis
| Haptoglobin | Hemopexin | Lactate dehydrogenase-1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | Value | T=0 hours | T=24 hours | T=0 hours | T=24 hours | T=0 hours | T=24 hours | ||||||
| Pooled | Pooled | Placebo | NO | Pooled | Pooled | Placebo | NO | Pooled | Pooled | Placebo | NO | ||
| PE | median | 29.0 | 46.5 | 31.2 | 49.5 | 21.2 | 22.7 | 23.3 | 22.0 | 92.6 | 90.8 | 93.0 | 67.7 |
| first | |||||||||||||
| quartile | 25.0 | 25.6 | 25.3 | 24.7 | 20.0 | 22.7 | 20.3 | 19.6 | 66.2 | 79.8 | 58.3 | 37.9 | |
| third | |||||||||||||
| quartile | 59.0 | 55.5 | 59.0 | 52.3 | 24.7 | 25.2 | 26.7 | 24.7 | 114.0 | 116.0 | 114.0 | 116.1 | |
| Controls | median | 16.6 | 15.7 | 20.6 | 20.0 | 1.3 | 0.5 | ||||||
| first | |||||||||||||
| quartile | 18.5 | 4.6 | 18.5 | 18.4 | 0.0 | 0.0 | |||||||
| third | |||||||||||||
| quartile | 23.5 | 24.8 | 23.5 | 24.0 | 4.4 | 6.0 | |||||||
| P value | 0.07* | 0.02 | 0.32** | 0.8 | 0.4 | 0.28 | 0.01 | 0.03 | 0.09 | ||||
P values comparing PE vs. Control from the Mann-Whitney U test;
P values comparing Placebo to NO from the Kruskal-Wallis repeated measures ANOVA