Table 4.
Guanylate cyclase activity* in platelet lysates
| Condition† | 2 min | 5 min | 10 min | |||||
|---|---|---|---|---|---|---|---|---|
| No PE | Mean | SEM | Mean | SEM | Mean | SEM | ||
| Unstimulated | 2.42 | 0.32 | 3.82 | 0.10 | 4.18 | 0.25 | ||
| NONO | 6.99 | 1.09 | 18.59 | 1.54 | 30.66 | 4.20 | ||
| Cinaciguat | 2.01 | 0.25 | 4.23 | 0.25 | 5.74 | 0.37 | ||
| Riociguat | 2.00 | 0.40 | 4.17 | 0.23 | 7.72 | 0.74 | ||
| Controls | Mean | SEM | Mean | SEM | Mean | SEM | ||
| Unstimulated | 4.62 | 0.38 | 7.90 | 1.70 | 12.45 | 2.46 | ||
| NONO | 30.34 | 1.36 | 76.19 | 5.58 | 132.43 | 8.59 | ||
| Cinaciguat | 5.20 | 0.41 | 11.86 | 1.19 | 24.52 | 3.39 | ||
| Riociguat | 4.92 | 0.47 | 10.34 | 1.33 | 21.65 | 2.31 | ||
*
pmol cGMP/10^6 cells
†
Concentrations of NON, Cinaciguate and Riociguat = 0.4 uM