Table 4.
Five cases with discordant Human epidermal growth factor receptor 2 immunohistochemistry digital image analysis/fluorescence in situ hybridization results
| Case number | HER2 DIA | HER2 DIA value | Original IHC | FISH | FISH copy number | FISH ratio | Additional FISH results |
|---|---|---|---|---|---|---|---|
| 1 | 1+ | 0.076643 | 2+ | P | 4.80 | 2.10 | D17Z1(ratio 1.68, copy number: 4.5) D17S122 (ratio 2.25, copy number: 4.6) |
| 2 | 1+ | 0.096429 | 2+ | P | 4.20 | 2.20 | D17Z1 (ratio 1.54, copy number: 3.70) |
| 3 | 1+ | 0.11514 | 1+ | P | 5.70 | 2.20 | D17Z1 (ratio 2.4, copy number: 4.4) |
| 4 | 3+ | 0.49328 | 2+ | N | 5.80 | 1.60 | D17Z1 (ratio 1.47, copy number: 5.0) D17S122 (ratio 1.74, copy number: 5.4) |
| 5 | 3+ | 0.54750 | 2+ | N | 4.90 | 1.40 | D17Z1 (ratio 1.74, copy number: 4.2) D17S122 (ratio is 1.59, copy number: 4.2) |
HER2: Human epidermal growth factor receptor 2, FISH: Fluorescence insitu hybridization, DIA: Digital image analysis, IHC: Immunohistochemistry