TABLE IV.
Hazard ratios of asthma-related ED visits and hospitalizations associated with cumulative DDD of statin use
| Database | Asthma-related ED visits or hospitalizations | Asthma-related ED visits | Asthma-related hospitalizations | ||||
|---|---|---|---|---|---|---|---|
| Statin | N | Events | AHR* (95% CI) | Events | AHR* (95% CI) | Events | AHR* (95% CI) |
| LHID2000+2005+2010 | |||||||
| 0 (no use) | 97,729 | 2,818 | Ref | 1,614 | Ref | 1,204 | Ref |
| 1 (cDDD ≤ 28) | 5,185 | 239 | 1.25 (1.09, 1.43)† | 116 | 1.2 (0.99, 1.45) | 123 | 1.33 (1.1, 1.61) |
| 2 (28 < cDDD ≤ 74.67) | 4,913 | 174 | 0.95 (0.81, 1.11) | 101 | 1.09 (0.89, 1.34) | 73 | 0.82 (0.65, 1.04) |
| 3 (74.67 < cDDD ≤ 172) | 4,825 | 121 | 0.67 (0.56, 0.81) | 65 | 0.72 (0.56, 0.93) | 56 | 0.64 (0.49, 0.84) |
| 4 (cDDD > 172) | 4,943 | 65 | 0.34 (0.27, 0.44) | 40 | 0.42 (0.31, 0.58) | 25 | 0.27 (0.18, 0.4) |
| LHID2000 | |||||||
| 0 (no use) | 35,265 | 1,102 | Ref | 609 | Ref | 493 | Ref |
| 1 (cDDD ≤ 28) | 1,776 | 86 | 1.62 (1.14, 2.28) | 41 | 1.57 (0.89, 2.74) | 45 | 1.65 (1.07, 2.56) |
| 2 (28 < cDDD ≤ 74.67) | 1,729 | 58 | 1.1 (0.71, 1.7) | 39 | 1.82 (1.04, 3.17) | 19 | 0.65 (0.32, 1.32) |
| 3 (74.67 < cDDD ≤ 172) | 1,650 | 44 | 0.78 (0.47, 1.28) | 24 | 1.25 (0.66, 2.4) | 20 | 0.47 (0.21, 1.07) |
| 4 (cDDD > 172) | 1,693 | 27 | 0.39 (0.21, 0.71) | 15 | 0.55 (0.24, 1.25) | 12 | 0.29 (0.12, 0.7) |
| LHID2005 | |||||||
| 0 (no use) | 34,721 | 1,015 | Ref | 579 | Ref | 436 | Ref |
| 1 (cDDD ≤ 28) | 1,858 | 82 | 1.07 (0.7, 1.64) | 38 | 1.23 (0.69, 2.18) | 44 | 0.93 (0.49, 1.78) |
| 2 (28 < cDDD ≤ 75) | 1,699 | 75 | 1.07 (0.68, 1.67) | 43 | 1.08 (0.57, 2.05) | 32 | 1.07 (0.58, 1.98) |
| 3 (75 < cDDD ≤ 172) | 1,753 | 43 | 0.59 (0.34, 1.01) | 26 | 0.77 (0.39, 1.52) | 17 | 0.41 (0.17, 1.01) |
| 4 (cDDD > 172) | 1,767 | 22 | 0.36 (0.2, 0.67) | 15 | 0.55 (0.27, 1.13) | 7 | 0.19 (0.06, 0.61) |
| LHID2010 | |||||||
| 0 (no use) | 31,512 | 829 | Ref | 501 | Ref | 328 | Ref |
| 1 (cDDD ≤ 28) | 1,742 | 83 | 1.9 (1.27, 2.83) | 45 | 2.48 (1.42, 4.36) | 38 | 1.53 (0.86, 2.69) |
| 2 (28 < cDDD ≤ 71) | 1,666 | 50 | 1.03 (0.61, 1.73) | 26 | 1 (0.43, 2.3) | 24 | 1.06 (0.55, 2.04) |
| 3 (71 < cDDD ≤ 168.33) | 1,606 | 38 | 0.65 (0.36, 1.18) | 16 | 0.55 (0.2, 1.5) | 22 | 0.73 (0.35, 1.51) |
| 4 (cDDD > 168.33) | 1,615 | 17 | 0.26 (0.12, 0.59) | 11 | 0.54 (0.22, 1.34) | 6 | 0.07 (0.01, 0.53) |
AHR, Adjusted hazards ratio; cDDD, cumulative DDD; CI, confidence interval; DDD, defined daily dose; ED, emergency department; LHID, Longitudinal Health Insurance Database.
*
Adjusted for age, sex, Deyo-Charlson index (exclude chronic pulmonary disease) in the 12 mo before the index date, asthma controller medication in the 12 mo before the index date, diagnosis of asthma in the 12 mo before the index date, and health care utilization in the 12 mo before the index date.
†
Significant results (P < .05) are in bold.