TABLE V.

Hazard ratios of asthma-related ED visits and hospitalizations associated with average DDD of statin use

Database		Asthma-related ED visits or hospitalizations		Asthma-related ED visits		Asthma-related hospitalizations
Statin	N	Events	AHR* (95% CI)	Events	AHR* (95% CI)	Events	AHR* (95% CI)
LHID2000+2005+2010
0 (no use)	97,730	2,818	Ref	1,614	Ref	1,204	Ref
1 (ave_DDD ≤ 0.67)	11,499	388	0.88 (0.79, 0.98)†	203	0.92 (0.79, 1.07)	185	0.85 (0.73, 1)
2 (ave_DDD > 0.67)	8,366	211	0.71 (0.61, 0.82)	119	0.79 (0.65, 0.95)	92	0.64 (0.52, 0.79)
LHID2000
0 (no use)	35,265	1,102	Ref	609	Ref	493	Ref
1 (ave_DDD ≤ 0.67)	3,985	132	0.96 (0.72, 1.3)	72	1.21 (0.78, 1.87)	60	0.82 (0.54, 1.23)
2 (ave_DDD > 0.67)	2,863	83	0.9 (0.63, 1.28)	47	1.28 (0.79, 2.08)	36	0.65 (0.38, 1.1)
LHID2005
0 (no use)	35,158	1,015	Ref	579	Ref	436	Ref
1 (ave_DDD ≤ 0.67)	4,185	146	0.69 (0.49, 0.97)	73	0.75 (0.47, 1.2)	73	0.64 (0.39, 1.05)
2 (ave_DDD > 0.67)	2,991	76	0.78 (0.54, 1.13)	49	1.04 (0.65, 1.68)	27	0.54 (0.29, 1)
LHID2010
0 (no use)	31,512	829	Ref	501	Ref	328	Ref
1 (ave_DDD ≤ 0.67)	3,814	126	1 (0.7, 1.42)	70	1.2 (0.71, 2.02)	56	0.88 (0.55, 1.41)
2 (ave_DDD > 0.67)	2,815	62	0.71 (0.46, 1.11)	28	0.87 (0.46, 1.64)	34	0.61 (0.33, 1.14)

AHR, Adjusted hazards ratio; ave_DDD, average DDD; CI, confidence interval; DDD, defined daily dose; ED, emergency department; LHID, Longitudinal Health Insurance Database.

^*Adjusted for age, sex, Deyo-Charlson index (exclude chronic pulmonary disease) in the 12 mo before the index date, asthma controller medication in the 12 mo before the index date, diagnosis of asthma in the 12 mo before the index date, and health care utilization in the 12 mo before the index date.

^†Significant results (P < .05) are in bold.