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TTR and its ligands. (A) Schematic structures of the thyroid hormone, thyroxine, a natural ligand of TTR, and of the TTR ligands tafamidis, an FDA-approved drug for FAP, diflunisal, available off-label for TTR amyloidoses, and AG10, a compound in clinical trial for FAC. (B) A ribbon diagram of TTR showing the tetramer structure composed of yellow, red, blue, and green monomers.
