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. Author manuscript; available in PMC: 2020 Dec 28.
Published in final edited form as: J Control Release. 2019 Oct 31;316:404–417. doi: 10.1016/j.jconrel.2019.10.028

Table 1:

Formulation details for all LNPs

Formulation lonizable lipid:mRNA ratio
Ionizable lipid Phospholipid Cholesterol PEG-Lipid
F01 2.5:1 40 4 53.5 2.5
F02 2.5:1 60 10 29.5 0.5
F03 7.5:1 40 28 28.5 3.5
F04 10:1 40 28 29.5 2.5
F05 12.5:1 40 22 35.0 3.0
F06 7.5:1 35 22 40.0 3.0
F07 10:1 35 22 39.5 3.5
F08 10:1 30 16 51.0 3.0
F09 5:1 30 16 51.5 2.5
F10 7.5:1 40 16 42.5 1.5
F11 5:1 35 16 46.5 2.5
F12 7.5:1 35 16 46.5 2.5
F13 10:1 35 16 46.5 2.5
F14 12.5:1 35 16 46.5 2.5
F15 15:1 35 16 46.5 2.5
F16 25:1 35 16 46.5 2.5