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Schematic of self-assembled Dox/HCVs nanoparticles and illustration of internalization procedure of nanoparticles. Active targeting Dox-loaded nanoplatform (Dox/HCVs) was self-assembled by HPCD grafted HA conjugates (HA-CD) with the help of the inclusion interaction of cyclodextrin and the bridging effect of VES. The core–shell nanoparticles will be internalized via HA-CD44 interaction by tumor cells to achieve the targeting delivery.
